Uncovering phenotypic inheritance from single cells with Microcolony-seq
Uncovering phenotypic inheritance from single cells with Microcolony-seqMicrocolony-seq systematically uncovers inherited phenotypic diversity directly from infected human samples, revealing that bacteria can retain long-term genetic and nongenetic memory from the host environment. These findings suggest that bacterial memory is widespread and may inform the development of strategies to target the multiple coexisting subpopulations within infections that can evade treatment.Microcolony-seq systematically uncovers inherited phenotypic diversity directly from infected human samples, revealing that bacteria can retain long-term genetic and nongenetic memory from the host environment. These findings suggest that bacterial memory is widespread and may inform the development of strategies to target the multiple coexisting subpopulations within infections that can evade treatment.Raya Faigenbaum-Romm, Noam Yedidi, Orit Gefen, Naama Katsowich-Nagar, Lior Aroeti, Irine Ronin, Maskit Bar-Meir, Ilan Rosenshine, Nathalie Q. Balabanhttps://www.cell.com/cell/fulltext/S0092-8674(25)00915-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 27, 2025
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