Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in MicrogliaExpression of c/EBPβ, a factor elevated in brains of patients with Alzheimer’s disease, is regulated post-translationally by COP1, an E3 ubiquitin ligase whose loss leads to microglial activation and neurotoxicity.Expression of c/EBPβ, a factor elevated in brains of patients with Alzheimer’s disease, is regulated post-translationally by COP1, an E3 ubiquitin ligase whose loss leads to microglial activation and neurotoxicity.Ada Ndoja, Rohit Reja, Seung-Hye Lee, Joshua D. Webster, Hai Ngu, Christopher M. Rose, Donald S. Kirkpatrick, Zora Modrusan, Ying-Jiun Jasmine Chen, Debra L. Dugger, Vineela Gandham, Luke Xie, Kim Newton, Vishva M. Dixithttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930876-X%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 14, 2020

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