Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regionsThis study presents a comprehensive atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions using advanced proteomics and isotope labeling. It reveals tissue-specific protein lifetimes, coordinated turnover within protein-protein interaction networks, peroxisomal turnover diversity, and the regulatory role of phosphorylation in protein stability, offering valuable insights into proteome homeostasis and tissue-specific functions.This study presents a comprehensive atlas of protein and phosphoprotein turnover across 16 mouse tissues and brain regions using advanced proteomics and isotope labeling. It reveals tissue-specific protein lifetimes, coordinated turnover within protein-protein interaction networks, peroxisomal turnover diversity, and the regulatory role of phosphorylation in protein stability, offering valuable insights into proteome homeostasis and tissue-specific functions.Wenxue Li, Abhijit Dasgupta, Ka Yang, Shisheng Wang, Nisha Hemandhar-Kumar, Surendhar R. Chepyala, Jay M. Yarbro, Zhenyi Hu, Barbora Salovska, Eugenio F. Fornasiero, Junmin Peng, Yansheng Liuhttps://www.cell.com/cell/fulltext/S0092-8674(25)00209-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 21, 2025

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