Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s diseaseThis study uncovers a previously unknown role for PHGDH in Alzheimer’s disease, showing that its transcriptional regulatory activity—distinct from its known metabolic function—initiates early disease pathology, opening new therapeutic avenues for late-onset Alzheimer’s.This study uncovers a previously unknown role for PHGDH in Alzheimer’s disease, showing that its transcriptional regulatory activity—distinct from its known metabolic function—initiates early disease pathology, opening new therapeutic avenues for late-onset Alzheimer’s.Junchen Chen, Fatemeh Hadi, Xingzhao Wen, Wenxin Zhao, Ming Xu, Shuanghong Xue, Pei Lin, Riccardo Calandrelli, John Lalith Charles Richard, Zhixuan Song, Jessica Li, Alborz Amani, Yang Liu, Xu Chen, Sheng Zhonghttps://www.cell.com/cell/fulltext/S0092-8674(25)00397-6?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 24, 2025

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