Topical therapy for regression and melanoma prevention of congenital giant neviLarge congenital nevi, or highly pigmented regions of skin, can present major cosmetic and psychosocial issues and have a significant chance of turning into malignant melanoma. However, current treatment methods provide only partial removal and can lead to scarring. Here, congenital nevus mouse models were developed and used to identify topical therapies that were highly effective at clearing nevi and protecting against melanoma formation.Large congenital nevi, or highly pigmented regions of skin, can present major cosmetic and psychosocial issues and have a significant chance of turning into malignant melanoma. However, current treatment methods provide only partial removal and can lead to scarring. Here, congenital nevus mouse models were developed and used to identify topical therapies that were highly effective at clearing nevi and protecting against melanoma formation.Yeon Sook Choi, Tal H. Erlich, Max von Franque, Inbal Rachmin, Jessica L. Flesher, Erik B. Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S. Dobry, Mack Su, Sharon Germana, Sebastian Lacher, Orly Freund, Ezra Feder, Jose L. Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R. Zakka, Marjan Azin, Christin E. Burd, Norman E. Sharpless, X. Shirley Liu, Clifford Meyer, William Gerald Austen, Branko Bojovic, Curtis L. Cetrulo, Martin C. Mihm, Dave S. Hoon, Shadmehr Demehri, Elena B. Hawryluk, David E. Fisherhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2822%2900472-X%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMay 13, 2022

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