The single-molecule accessibility landscape of newly replicated mammalian chromatinBy developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unwrapped, irregularly spaced nucleosomal species compared with steady-state chromatin. They discover direct regulatory roles for sequence-non-specific chaperone complexes and sequence-specific transcription factors in resetting the single-molecular nucleosome landscape following replication.By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unwrapped, irregularly spaced nucleosomal species compared with steady-state chromatin. They discover direct regulatory roles for sequence-non-specific chaperone complexes and sequence-specific transcription factors in resetting the single-molecular nucleosome landscape following replication.Megan S. Ostrowski, Marty G. Yang, Colin P. McNally, Nour J. Abdulhay, Simai Wang, Keerthi Renduchintala, Iryna Irkliyenko, Alva Biran, Brandon T.L. Chew, Ayush D. Midha, Emily V. Wong, Jonathan Sandoval, Isha H. Jain, Anja Groth, Elphège P. Nora, Hani Goodarzi, Vijay Ramanihttps://www.cell.com/cell/fulltext/S0092-8674(24)01255-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 16, 2024

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