The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune functionCAR-T cells expressing an immunostimulatory RNA achieve enhanced efficacy in solid tumor mouse models with CAR antigen loss by improving autonomous CAR-T cell function and promoting endogenous immunity through preferential uptake of RNA-containing extracellular vesicles in innate immune cells over tumor cells.CAR-T cells expressing an immunostimulatory RNA achieve enhanced efficacy in solid tumor mouse models with CAR antigen loss by improving autonomous CAR-T cell function and promoting endogenous immunity through preferential uptake of RNA-containing extracellular vesicles in innate immune cells over tumor cells.Lexus R. Johnson, Daniel Y. Lee, Jacqueline S. Eacret, Darwin Ye, Carl H. June, Andy J. Minnhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2900946-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 31, 2021

Powered by WPeMatico