TGF-β and RAS jointly unmask primed enhancers to drive metastasisDuring carcinoma metastasis, malignant progenitors undergo a TGF-β-dependent EMT associated with fibroblast activation and extracellular matrix remodeling in the tumor microenvironment. RAS-activated RREB1 primes enhancers of EMT and fibrogenic genes in lung adenocarcinoma cells for activation by chromatin remodeling complexes that the TGF-β/SMAD pathway recruits to these enhancers. Inhibiting RREB1 disables this pro-metastatic process.During carcinoma metastasis, malignant progenitors undergo a TGF-β-dependent EMT associated with fibroblast activation and extracellular matrix remodeling in the tumor microenvironment. RAS-activated RREB1 primes enhancers of EMT and fibrogenic genes in lung adenocarcinoma cells for activation by chromatin remodeling complexes that the TGF-β/SMAD pathway recruits to these enhancers. Inhibiting RREB1 disables this pro-metastatic process.Jun Ho Lee, Francisco J. Sánchez-Rivera, Lan He, Harihar Basnet, Fei Xavier Chen, Elena Spina, Liangji Li, Carles Torner, Jason E. Chan, Dig Vijay Kumar Yarlagadda, Jin Suk Park, Carleigh Sussman, Charles M. Rudin, Scott W. Lowe, Tuomas Tammela, Maria J. Macias, Richard P. Koche, Joan Massaguéhttps://www.cell.com/cell/fulltext/S0092-8674(24)00905-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 7, 2024

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