TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALSTDP-43 causes inflammation in ALS by stimulating mitochondrial DNA release, which is subsequently sensed by the cytosolic cGAS/STING pathway, suggesting that inhibition of cGAS/STING could help alleviate inflammation-related damage in ALS.TDP-43 causes inflammation in ALS by stimulating mitochondrial DNA release, which is subsequently sensed by the cytosolic cGAS/STING pathway, suggesting that inhibition of cGAS/STING could help alleviate inflammation-related damage in ALS.Chien-Hsiung Yu, Sophia Davidson, Cassandra R. Harapas, James B. Hilton, Michael J. Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R. Balka, Dale J. Calleja, Fiona Moghaddas, Erya Ni, Catriona A. McLean, Andre L. Samson, Shiraz Tyebji, Christopher J. Tonkin, Christopher R. Bye, Bradley J. Turner, Genevieve Pepin, Michael P. Gantier, Kelly L. Rogers, Kate McArthur, Peter J. Crouch, Seth L. Mastershttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931161-2%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 8, 2020

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