Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapyDetailed characterization of the recognition and activation characteristics of T cells from successful therapy against melanoma unveils that individual T cells recognize multiple tumor-associated antigens simultaneously; elicitation or engineering of such “multipronged” T cells may be an effective means of enhancing the efficacy of T cell cancer therapy.Detailed characterization of the recognition and activation characteristics of T cells from successful therapy against melanoma unveils that individual T cells recognize multiple tumor-associated antigens simultaneously; elicitation or engineering of such “multipronged” T cells may be an effective means of enhancing the efficacy of T cell cancer therapy.Garry Dolton, Cristina Rius, Aaron Wall, Barbara Szomolay, Valentina Bianchi, Sarah A.E. Galloway, Md Samiul Hasan, Théo Morin, Marine E. Caillaud, Hannah L. Thomas, Sarah Theaker, Li Rong Tan, Anna Fuller, Katie Topley, Mateusz Legut, Meriem Attaf, Jade R. Hopkins, Enas Behiry, Joanna Zabkiewicz, Caroline Alvares, Angharad Lloyd, Amber Rogers, Peter Henley, Christopher Fegan, Oliver Ottmann, Stephen Man, Michael D. Crowther, Marco Donia, Inge Marie Svane, David K. Cole, Paul E. Brown, Pierre Rizkallah, Andrew K. Sewellhttps://www.cell.com/cell/fulltext/S0092-8674(23)00696-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 25, 2023

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