Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesisThe thrombopoietin-MPL axis plays essential roles in hematopoietic stem cell biology and platelet production. Cryo-EM structure of the dimeric thrombopoietin-MPL receptor complex enabled design of biased agonists that tune intracellular signaling, thereby uncoupling the primary opposing functions of thrombopoietin signaling, hematopoietic stem cell maintenance, and differentiation.The thrombopoietin-MPL axis plays essential roles in hematopoietic stem cell biology and platelet production. Cryo-EM structure of the dimeric thrombopoietin-MPL receptor complex enabled design of biased agonists that tune intracellular signaling, thereby uncoupling the primary opposing functions of thrombopoietin signaling, hematopoietic stem cell maintenance, and differentiation.Naotaka Tsutsumi, Zahra Masoumi, Sophie C. James, Julie A. Tucker, Hauke Winkelmann, William Grey, Lora K. Picton, Lucie Moss, Steven C. Wilson, Nathanael A. Caveney, Kevin M. Jude, Cornelius Gati, Jacob Piehler, Ian S. Hitchcock, K. Christopher Garciahttps://www.cell.com/cell/fulltext/S0092-8674(23)00852-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 26, 2023

Powered by WPeMatico