Structure of gut microbial glycolipid modulates host inflammatory responseStructural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by TLR4 endocytosis and lipid droplet formation. This lipid A-structure-driven immunomodulation via IFN-β contributes to the maintenance of colonic RORγt+ Tregs during homeostasis and helps mitigate colonic inflammation.Structural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by TLR4 endocytosis and lipid droplet formation. This lipid A-structure-driven immunomodulation via IFN-β contributes to the maintenance of colonic RORγt+ Tregs during homeostasis and helps mitigate colonic inflammation.Hyoung-Soo Cho, Ji-Sun Yoo, Xinyang Song, Byoungsook Goh, Alos Diallo, Jesang Lee, Sumin Son, Yoon Soo Hwang, Seung Bum Park, Sungwhan F. Oh, Dennis L. Kasperhttps://www.cell.com/cell/fulltext/S0092-8674(25)00566-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 23, 2025

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