Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicityPyroptosis is an immunogenic cell death that can promote antitumor immunity. This study identified a small molecule agonist of GSDMD that induced GSDMD pore formation and pyroptosis without cleavage and showed that pulsed and low-level pyroptosis induction in cancer cells is a strategy for cancer immunotherapy with little toxicity.Pyroptosis is an immunogenic cell death that can promote antitumor immunity. This study identified a small molecule agonist of GSDMD that induced GSDMD pore formation and pyroptosis without cleavage and showed that pulsed and low-level pyroptosis induction in cancer cells is a strategy for cancer immunotherapy with little toxicity.Pietro Fontana, Gang Du, Ying Zhang, Haiwei Zhang, Setu M. Vora, Jun Jacob Hu, Ming Shi, Ahmet B. Tufan, Liam B. Healy, Shiyu Xia, Dian-Jang Lee, Zhouyihan Li, Pilar Baldominos, Heng Ru, Hongbo R. Luo, Judith Agudo, Judy Lieberman, Hao Wuhttps://www.cell.com/cell/fulltext/S0092-8674(24)00898-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignSeptember 7, 2024

Powered by WPeMatico