Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilienceA single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion of vulnerable neurons and exhaustion of activated glial cells, while preserved epigenomic stability supports cognitive function and resilience.A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion of vulnerable neurons and exhaustion of activated glial cells, while preserved epigenomic stability supports cognitive function and resilience.Zunpeng Liu, Shanshan Zhang, Benjamin T. James, Kyriaki Galani, Riley J. Mangan, Stuart Benjamin Fass, Chuqian Liang, Manoj M. Wagle, Carles A. Boix, Yosuke Tanigawa, Sukwon Yun, Yena Sung, Xushen Xiong, Na Sun, Lei Hou, Martin Wohlwend, Mufan Qiu, Xikun Han, Lei Xiong, Efthalia Preka, Lei Huang, William F. Li, Li-Lun Ho, Amy Grayson, Julio Mantero, Alexey Kozlenkov, Hansruedi Mathys, Tianlong Chen, Stella Dracheva, David A. Bennett, Li-Huei Tsai, Manolis Kellishttps://www.cell.com/cell/fulltext/S0092-8674(25)00733-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 2, 2025

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