Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable TumorsTumors that have high levels of mutations within microsatellites (MSI-H) demonstrate specific frameshifts that are then expressed at the RNA and protein levels across endometrial, colorectal, and stomach cancers. Epitopes from these frameshifts yield neoantigens that are distinct from self and viral antigens and elicit T cell responses.Tumors that have high levels of mutations within microsatellites (MSI-H) demonstrate specific frameshifts that are then expressed at the RNA and protein levels across endometrial, colorectal, and stomach cancers. Epitopes from these frameshifts yield neoantigens that are distinct from self and viral antigens and elicit T cell responses.Vladimir Roudko, Cansu Cimen Bozkus, Theofano Orfanelli, Christopher B. McClain, Caitlin Carr, Timothy O’Donnell, Lauren Chakraborty, Robert Samstein, Kuan-lin Huang, Stephanie V. Blank, Benjamin Greenbaum, Nina Bhardwajhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931463-X%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 1, 2020

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