Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticityThe postsynaptic density (PSD) condensates in neuronal synapses are soft glass-like structures due to the formation of highly percolated protein-protein interaction networks. Shank3 oligomerization is critical for the soft glass-like PSD condensate formation. Defects in Shank3 oligomerization soften PSD, impair synaptic transmissions, and cause autism-like phenotypes in mice.The postsynaptic density (PSD) condensates in neuronal synapses are soft glass-like structures due to the formation of highly percolated protein-protein interaction networks. Shank3 oligomerization is critical for the soft glass-like PSD condensate formation. Defects in Shank3 oligomerization soften PSD, impair synaptic transmissions, and cause autism-like phenotypes in mice.Bowen Jia, Zeyu Shen, Shihan Zhu, Jingguo Huang, Zhitao Liao, Shuaizhu Zhao, Hao Li, Shiwen Chen, Yang Xu, Yu Wang, Haitang Peng, Guanhua Bai, Youming Lu, Penger Tong, Wucheng Tao, Mingjie Zhanghttps://www.cell.com/cell/fulltext/S0092-8674(25)00913-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 23, 2025

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