Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders

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Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degradersDiscovery of a molecular glue promoting TRIM21 and NUP98 interaction enables the rational design of TRIM21-based PROTAC degraders for the selective elimination of multimeric proteins.Discovery of a molecular glue promoting TRIM21 and NUP98 interaction enables the rational design of TRIM21-based PROTAC degraders for the selective elimination of multimeric proteins.Panrui Lu, Yalong Cheng, Lei Xue, Xintong Ren, Xilong Xu, Chenglong Chen, Longzhi Cao, Jiaojiao Li, Qingcui Wu, Shan Sun, Junjie Hou, Wei Jia, Wei Wang, Yan Ma, Zhaodi Jiang, Chao Li, Xiangbing Qi, Niu Huang, Ting Hanhttps://www.cell.com/cell/fulltext/S0092-8674(24)01197-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 2, 2024

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