Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxinsHybrid structure-sequence mining and biochemical/structural characterization trace the evolutionary origins of CRISPR-Cas13, elucidating how their RNA-guided mechanism likely evolved from an ancient scaffold comprising an RNase toxin and an ncRNA antitoxin.Hybrid structure-sequence mining and biochemical/structural characterization trace the evolutionary origins of CRISPR-Cas13, elucidating how their RNA-guided mechanism likely evolved from an ancient scaffold comprising an RNase toxin and an ncRNA antitoxin.Shai Zilberzwige-Tal, Han Altae-Tran, Soumya Kannan, Max E. Wilkinson, Samuel Chau-Duy-Tam Vo, Daniel Strebinger, KeHuan K. Edmonds, Chun-Chen Jerry Yao, Kepler S. Mears, Sergey A. Shmakov, Kira S. Makarova, Rhiannon K. Macrae, Eugene V. Koonin, Feng Zhanghttps://www.cell.com/cell/fulltext/S0092-8674(25)00103-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 19, 2025

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