Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stressThe stability of BACH1 is controlled by two F-box proteins, FBXO22 and FBXL17. There are two forms of the BACH1 quaternary structure degrons that are encoded by its dimeric BTB domain. FBXO22 recognizes the intact dimeric BTB domain, whereas FBXL17 targets and remodels the BTB domain dimer when destabilized by S-nitrosylation.The stability of BACH1 is controlled by two F-box proteins, FBXO22 and FBXL17. There are two forms of the BACH1 quaternary structure degrons that are encoded by its dimeric BTB domain. FBXO22 recognizes the intact dimeric BTB domain, whereas FBXL17 targets and remodels the BTB domain dimer when destabilized by S-nitrosylation.Shiyun Cao, Sheena Faye Garcia, Huigang Shi, Ellie I. James, Yuki Kito, Hui Shi, Haibin Mao, Sharon Kaisari, Gergely Rona, Sophia Deng, Hailey V. Goldberg, Jackeline Ponce, Beatrix Ueberheide, Luca Lignitto, Miklos Guttman, Michele Pagano, Ning Zhenghttps://www.cell.com/cell/fulltext/S0092-8674(24)01188-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 6, 2024

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