Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaquesA two-step approach against HIV can reproducibly generate a potent plasma repertoire of broadly neutralizing antibodies in macaques. The first step utilizes vaccination to raise B cell responses to a conserved viral peptide, then the second step induces effective plasma neutralization by re-challenging those B cells with a virus that serves as an evolving source of B cell stimulation, similar to natural infection.A two-step approach against HIV can reproducibly generate a potent plasma repertoire of broadly neutralizing antibodies in macaques. The first step utilizes vaccination to raise B cell responses to a conserved viral peptide, then the second step induces effective plasma neutralization by re-challenging those B cells with a virus that serves as an evolving source of B cell stimulation, similar to natural infection.Hua Wang, Cheng Cheng, James L. Dal Santo, Chen-Hsiang Shen, Tatsiana Bylund, Amy R. Henry, Colin A. Howe, Juyun Hwang, Nicholas C. Morano, Daniel J. Morris, Sergei Pletnev, Ryan S. Roark, Tongqing Zhou, Bryan T. Hansen, Forrest H. Hoyt, Timothy S. Johnston, Shuyi Wang, Baoshan Zhang, David R. Ambrozak, Jordan E. Becker, Michael F. Bender, Anita Changela, Ridhi Chaudhary, Martin Corcoran, Angela R. Corrigan, Kathryn E. Foulds, Yicheng Guo, Myungjin Lee, Yingying Li, Bob C. Lin, Tracy Liu, Mark K. Louder, Marco Mandolesi, Rosemarie D. Mason, Krisha McKee, Vinod Nair, Sijy O’Dell, Adam S. Olia, Li Ou, Amarendra Pegu, Nagarajan Raju, Reda Rawi, Jesmine Roberts-Torres, Edward K. Sarfo, Mallika Sastry, Andrew J. Schaub, Stephen D. Schmidt, Chaim A. Schramm, Cindi L. Schwartz, Sarah C. Smith, Tyler Stephens, Jonathan Stuckey, I-Ting Teng, John-Paul Todd, Yaroslav Tsybovsky, David J. Van Wazer, Shuishu Wang, Nicole A. Doria-Rose, Elizabeth R. Fischer, Ivelin S. Georgiev, Gunilla B. Karlsson Hedestam, Zizhang Sheng, Ruth A. Woodward, Daniel C. Douek, Richard A. Koup, Theodore C. Pierson, Lawrence Shapiro, George M. Shaw, John R. Mascola, Peter D. Kwonghttps://www.cell.com/cell/fulltext/S0092-8674(24)01151-6?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 29, 2024

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