Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancerSelective pressure for biallelic inactivation varies widely across tumor suppressor genes and is a biomarker for therapeutic response, providing new insights into Knudson’s two-hit hypothesis.Selective pressure for biallelic inactivation varies widely across tumor suppressor genes and is a biomarker for therapeutic response, providing new insights into Knudson’s two-hit hypothesis.Mark Zucker, Maria A. Perry, Samuel I. Gould, Arielle Elkrief, Anton Safonov, Rohit Thummalapalli, Miika Mehine, Debyani Chakravarty, A. Rose Brannon, Marc Ladanyi, Pedram Razavi, Mark T.A. Donoghue, Yonina R. Murciano-Goroff, Kristiana Grigoriadis, Nicholas McGranahan, Mariam Jamal-Hanjani, Charles Swanton, Yuan Chen, Ronglai Shen, Sarat Chandarlapaty, David B. Solit, Nikolaus Schultz, Michael F. Berger, Jason Chang, Adam J. Schoenfeld, Francisco J. Sánchez-Rivera, Ed Reznik, Chaitanya Bandlamudihttps://www.cell.com/cell/fulltext/S0092-8674(24)01327-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 19, 2024

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