Organ-specific electrophile responsivity mapping in live C. elegansContext-specific protein reactivity is a cornerstone of biological stress responsivity and thus has important ramifications for drug discovery. No current method can inform on these parameters. Here, we debut a method that cartographs locale-specific actionability to reactive metabolites. Cyp-33e1, a gut-specific responder, emerged to partition between electrophile-driven localized enzymatic turnover that triggers gut-specific metabolite production shaping global lipid storage and localized electrophile sensing that marshals global stress response.Context-specific protein reactivity is a cornerstone of biological stress responsivity and thus has important ramifications for drug discovery. No current method can inform on these parameters. Here, we debut a method that cartographs locale-specific actionability to reactive metabolites. Cyp-33e1, a gut-specific responder, emerged to partition between electrophile-driven localized enzymatic turnover that triggers gut-specific metabolite production shaping global lipid storage and localized electrophile sensing that marshals global stress response.Jinmin Liu, Amogh Kulkarni, Yong-Qi Gao, Daniel A. Urul, Romain Hamelin, Balázs Á. Novotny, Marcus J.C. Long, Yimon Ayehttps://www.cell.com/cell/fulltext/S0092-8674(24)01190-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 6, 2024

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