Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolutionOngoing chromothripsis shapes genomic evolution in a diverse range of sarcomas and carcinomas. High-grade osteosarcoma is predominantly driven by the mechanism of loss-translocation-amplification chromothripsis, and genome-wide loss of heterozygosity shows prognostic potential.Ongoing chromothripsis shapes genomic evolution in a diverse range of sarcomas and carcinomas. High-grade osteosarcoma is predominantly driven by the mechanism of loss-translocation-amplification chromothripsis, and genome-wide loss of heterozygosity shows prognostic potential.Jose Espejo Valle-Inclan, Solange De Noon, Katherine Trevers, Hillary Elrick, Ianthe A.E.M. van Belzen, Sonia Zumalave, Carolin M. Sauer, Mélanie Tanguy, Thomas Butters, Francesc Muyas, Alistair G. Rust, Fernanda Amary, Roberto Tirabosco, Adam Giess, Alona Sosinsky, Greg Elgar, Adrienne M. Flanagan, Isidro Cortés-Cirianohttps://www.cell.com/cell/fulltext/S0092-8674(24)01418-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 15, 2025

Powered by WPeMatico