Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

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Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic RedundancyMetabolic redundancy differs according to microenvironments, making the glycolysis gene Gpi1 dispensable for homeostatic Th17 cells in normal tissue but essential for pathogenic Th17 cells in hypoxic inflamed tissue.Metabolic redundancy differs according to microenvironments, making the glycolysis gene Gpi1 dispensable for homeostatic Th17 cells in normal tissue but essential for pathogenic Th17 cells in hypoxic inflamed tissue.Lin Wu, Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan-Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman, Rahul Satija, Dan R. Littmanhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930745-5%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 2, 2020

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