Mucus sialylation determines intestinal host-commensal homeostasisSialylation plays an essential role in protecting mucus barrier integrity from bacterial degradation and is governed by ST6GALNAC1 (ST6), a local sialyltransferase in the gut. ST6-mediated mucus homeostasis controls commensalism to establish intestinal host-microbe symbiosis. ST6 deficiency disrupts this mutualism, increasing susceptibility to intestinal inflammation.Sialylation plays an essential role in protecting mucus barrier integrity from bacterial degradation and is governed by ST6GALNAC1 (ST6), a local sialyltransferase in the gut. ST6-mediated mucus homeostasis controls commensalism to establish intestinal host-microbe symbiosis. ST6 deficiency disrupts this mutualism, increasing susceptibility to intestinal inflammation.Yikun Yao, Girak Kim, Samantha Shafer, Zuojia Chen, Satoshi Kubo, Yanlong Ji, Jialie Luo, Weiming Yang, Sebastian P. Perner, Chrysi Kanellopoulou, Ann Y. Park, Ping Jiang, Jian Li, Safa Baris, Elif Karakoc Aydiner, Deniz Ertem, Daniel J. Mulder, Neil Warner, Anne M. Griffiths, Chani Topf-Olivestone, Michal Kori, Lael Werner, Jodie Ouahed, Michael Field, Chengyu Liu, Benjamin Schwarz, Catharine M. Bosio, Sundar Ganesan, Jian Song, Henning Urlaub, Thomas Oellerich, Stacy A. Malaker, Lixin Zheng, Carolyn R. Bertozzi, Yu Zhang, Helen Matthews, Will Montgomery, Han-Yu Shih, Jiansheng Jiang, Marcus Jones, Aris Baras, Alan Shuldiner, Claudia Gonzaga-Jauregui, Scott B. Snapper, Aleixo M. Muise, Dror S. Shouval, Ahmet Ozen, Kuan-Ting Pan, Chuan Wu, Michael J. Lenardohttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2822%2900193-3%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 18, 2022

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