mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variantThe SARS-CoV-2 Omicron variant exhibits escape from vaccine-induced humoral immunity, however, a third dose of COVID-19 mRNA vaccine elicited humoral immunity is capable of cross-neutralizing the virus. In addition, pseudovirus with Omicron spike exhibited more efficient transduction of ACE2-expressing target cells than other variants.The SARS-CoV-2 Omicron variant exhibits escape from vaccine-induced humoral immunity, however, a third dose of COVID-19 mRNA vaccine elicited humoral immunity is capable of cross-neutralizing the virus. In addition, pseudovirus with Omicron spike exhibited more efficient transduction of ACE2-expressing target cells than other variants.Wilfredo F. Garcia-Beltran, Kerri J. St. Denis, Angelique Hoelzemer, Evan C. Lam, Adam D. Nitido, Maegan L. Sheehan, Cristhian Berrios, Onosereme Ofoman, Christina C. Chang, Blake M. Hauser, Jared Feldman, Alex L. Roederer, David J. Gregory, Mark C. Poznansky, Aaron G. Schmidt, A. John Iafrate, Vivek Naranbhai, Alejandro B. Balazshttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2901496-3%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 24, 2021

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