Molecular basis of proton sensing by G protein-coupled receptorsHoward et al. combine mechanistic deep mutational scanning, cryo-EM, and constant-pH molecular dynamics simulations to provide a holistic view of proton activation in human pH-sensitive GPCRs.Howard et al. combine mechanistic deep mutational scanning, cryo-EM, and constant-pH molecular dynamics simulations to provide a holistic view of proton activation in human pH-sensitive GPCRs.Matthew K. Howard, Nicholas Hoppe, Xi-Ping Huang, Darko Mitrovic, Christian B. Billesbølle, Christian B. Macdonald, Eshan Mehrotra, Patrick Rockefeller Grimes, Donovan D. Trinidad, Lucie Delemotte, Justin G. English, Willow Coyote-Maestas, Aashish Manglikhttps://www.cell.com/cell/fulltext/S0092-8674(24)01373-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 3, 2025

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