Modeling epigenetic lesions that cause gliomasA mouse model of IDH-mutant glioma is established by simulating downstream epigenetic lesions that activate the PDGFRA oncogene and silence the CDKN2A tumor suppressor. The study provides insight into glioma mechanism, putative cell of origin and disease risk.A mouse model of IDH-mutant glioma is established by simulating downstream epigenetic lesions that activate the PDGFRA oncogene and silence the CDKN2A tumor suppressor. The study provides insight into glioma mechanism, putative cell of origin and disease risk.Gilbert J. Rahme, Nauman M. Javed, Kaitlyn L. Puorro, Shouhui Xin, Volker Hovestadt, Sarah E. Johnstone, Bradley E. Bernsteinhttps://www.cell.com/cell/fulltext/S0092-8674(23)00729-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 26, 2023

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