Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironmentThe gut microbiota tunes the pro/anti-tumorigenic balance of the tumor microenvironment via a STING-type I IFN-dependent mechanism. Feeding a high-fiber diet or transferring the fecal microbiota from immune checkpoint blockade (ICB) responder melanoma individuals triggers this pathway and programs intratumoral mononuclear phagocytes to promote anticancer immunity and ICB efficacy.The gut microbiota tunes the pro/anti-tumorigenic balance of the tumor microenvironment via a STING-type I IFN-dependent mechanism. Feeding a high-fiber diet or transferring the fecal microbiota from immune checkpoint blockade (ICB) responder melanoma individuals triggers this pathway and programs intratumoral mononuclear phagocytes to promote anticancer immunity and ICB efficacy.Khiem C. Lam, Romina E. Araya, April Huang, Quanyi Chen, Martina Di Modica, Richard R. Rodrigues, Amélie Lopès, Sarah B. Johnson, Benjamin Schwarz, Eric Bohrnsen, Alexandria P. Cogdill, Catharine M. Bosio, Jennifer A. Wargo, Maxwell P. Lee, Romina S. Goldszmidhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2821%2901066-7%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 8, 2021

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