Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potentialPeripheral lymph nodes are monitored by a unique assortment of sensory neurons with strong enrichment for peptidergic nociceptors. By combining whole-mount immunolabeling, retrograde neuronal tracing, single-cell genomics, and optogenetic approaches, Huang et al. uncover a bidirectional neuroimmune communication axis in lymph nodes, where sensory neurons not only sense lymph node immune status but also, when activated, modulate gene expression in immune and stromal cells.Peripheral lymph nodes are monitored by a unique assortment of sensory neurons with strong enrichment for peptidergic nociceptors. By combining whole-mount immunolabeling, retrograde neuronal tracing, single-cell genomics, and optogenetic approaches, Huang et al. uncover a bidirectional neuroimmune communication axis in lymph nodes, where sensory neurons not only sense lymph node immune status but also, when activated, modulate gene expression in immune and stromal cells.Siyi Huang, Carly G.K. Ziegler, John Austin, Najat Mannoun, Marko Vukovic, Jose Ordovas-Montanes, Alex K. Shalek, Ulrich H. von Andrianhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2931564-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignDecember 17, 2020

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