Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patientsIn a longitudinal analysis of SARS-CoV-2 infected people, Kreer et al find highly potent neutralizing antibodies, which use a broad spectrum usage of variable (V) genes and show low levels of somatic mutations. They also isolate potential precursors of these SARS-CoV-2 neutralizing antibodies from virus-naïve individuals, sampled before the COVID-19 pandemic, to provide evidence that neutralizing antibodies can be readily generated from existing germline antibody sequences found in the general population.In a longitudinal analysis of SARS-CoV-2 infected people, Kreer et al find highly potent neutralizing antibodies, which use a broad spectrum usage of variable (V) genes and show low levels of somatic mutations. They also isolate potential precursors of these SARS-CoV-2 neutralizing antibodies from virus-naïve individuals, sampled before the COVID-19 pandemic, to provide evidence that neutralizing antibodies can be readily generated from existing germline antibody sequences found in the general population.Christoph Kreer, Matthias Zehner, Timm Weber, Meryem S. Ercanoglu, Lutz Gieselmann, Cornelius Rohde, Sandro Halwe, Michael Korenkov, Philipp Schommers, Kanika Vanshylla, Veronica Di Cristanziano, Hanna Janicki, Reinhild Brinker, Artem Ashurov, Verena Krähling, Alexandra Kupke, Hadas Cohen-Dvashi, Manuel Koch, Jan Mathis Eckert, Simone Lederer, Nico Pfeifer, Timo Wolf, Maria J.G.T. Vehreschild, Clemens Wendtner, Ron Diskin, Henning Gruell, Stephan Becker, Florian Kleinhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930821-7%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 8, 2020

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