IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer
IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancerMechanisms dictating the form of chemotherapy-induced cancer cell death are elusive. This study reports that immunologically cold triple-negative breast cancer (TNBC) hijacks an ancient ER stress response to silence taxane-based chemotherapy-induced danger signals and avoid pore-forming inflammatory pyroptosis to achieve immune evasion.Mechanisms dictating the form of chemotherapy-induced cancer cell death are elusive. This study reports that immunologically cold triple-negative breast cancer (TNBC) hijacks an ancient ER stress response to silence taxane-based chemotherapy-induced danger signals and avoid pore-forming inflammatory pyroptosis to achieve immune evasion.Longyong Xu, Fanglue Peng, Qin Luo, Yao Ding, Fei Yuan, Liting Zheng, Wei He, Sophie S. Zhang, Xin Fu, Jin Liu, Ayse Sena Mutlu, Shuyue Wang, Ralf Bernd Nehring, Xingyu Li, Qianzi Tang, Catherine Li, Xiangdong Lv, Lacey E. Dobrolecki, Weijie Zhang, Dong Han, Na Zhao, Eric Jaehnig, Jingyi Wang, Weiche Wu, Davis A. Graham, Yumei Li, Rui Chen, Weiyi Peng, Yiwen Chen, Andre Catic, Zhibin Zhang, Bing Zhang, Anthony M. Mustoe, Albert C. Koong, George Miles, Michael T. Lewis, Meng C. Wang, Susan M. Rosenberg, Bert W. O’Malley, Thomas F. Westbrook, Han Xu, Xiang H.-F. Zhang, C. Kent Osborne, Jin Billy Li, Matthew J. Ellis, Mothaffar F. Rimawi, Jeffrey M. Rosen, Xi Chenhttps://www.cell.com/cell/fulltext/S0092-8674(24)01090-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 17, 2024
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