Human monoclonal antibodies targeting A35 protect from death caused by mpoxThree potent mAbs against the conserved MPXV A35 protein block viral spread, protect against lethal infection in mice, and align with protective antibody responses in convalescent humans, establishing A35 as a key target for next-generation orthopoxvirus therapies.Three potent mAbs against the conserved MPXV A35 protein block viral spread, protect against lethal infection in mice, and align with protective antibody responses in convalescent humans, establishing A35 as a key target for next-generation orthopoxvirus therapies.Raianna F. Fantin, Meng Yuan, Seok-Chan Park, Bailey Bozarth, Hallie Cohn, Maxinne Ignacio, Patricia Earl, Alesandro Civljak, Gabriel Laghlali, Ding Zhang, Xueyong Zhu, Jameson Crandell, Valter Monteiro, Jordan J. Clark, Catherine Cotter, Martin Burkhardt, Gagandeep Singh, Prajakta Warang, Juan García-Bernalt Diego, Komal Srivastava, Luz A. Lugo, Lauren Pischel, PVI study group, Inci Yildirim, Saad B. Omer, Daniel da Silva, Florian Krammer, Goran Bajic, Viviana Simon, Michael Schotsaert, Carolina Lucas, Ian A. Wilson, Bernard Moss, Camila H. Coelhohttps://www.cell.com/cell/fulltext/S0092-8674(25)00918-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignAugust 27, 2025

Powered by WPeMatico