Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteriaX-linked recessive human MCTS1 deficiency underlies mycobacterial disease by impairing JAK2 translation in innate-like T lymphocytes, thereby decreasing the IL-23-dependent production of IFN-γ by these cells upon mycobacterial challenge.X-linked recessive human MCTS1 deficiency underlies mycobacterial disease by impairing JAK2 translation in innate-like T lymphocytes, thereby decreasing the IL-23-dependent production of IFN-γ by these cells upon mycobacterial challenge.Jonathan Bohlen, Qinhua Zhou, Quentin Philippot, Masato Ogishi, Darawan Rinchai, Tea Nieminen, Simin Seyedpour, Nima Parvaneh, Nima Rezaei, Niloufar Yazdanpanah, Mana Momenilandi, Clément Conil, Anna-Lena Neehus, Carltin Schmidt, Carlos A. Arango-Franco, Tom Le Voyer, Taushif Khan, Rui Yang, Julia Puchan, Lucia Erazo, Mykola Roiuk, Taja Vatovec, Zarah Janda, Ivan Bagarić, Marie Materna, Adrian Gervais, Hailun Li, Jérémie Rosain, Jessica N Peel, Yoann Seeleuthner, Ji Eun Han, Anne-Sophie L’Honneur, Marcela Moncada-Vélez, Marta Martin-Fernandez, Michael E. Horesh, Tatiana Kochetkov, Monika Schmidt, Mohammed A. AlShehri, Eeva Salo, Harri Saxen, Gehad ElGhazali, Ahmad Yatim, Camille Soudée, Federica Sallusto, Armin Ensser, Nico Marr, Peng Zhang, Dusan Bogunovic, Aurélie Cobat, Mohammad Shahrooei, Vivien Béziat, Laurent Abel, Xiaochuan Wang, Stéphanie Boisson-Dupuis, Aurelio A. Teleman, Jacinta Bustamante, Qian Zhang, Jean-Laurent Casanovahttps://www.cell.com/cell/fulltext/S0092-8674(23)01078-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 24, 2023

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