GUK1 activation is a metabolic liability in lung cancerSchneider et al. identify guanylate kinase 1 (GUK1), a GDP-synthesizing enzyme, as a target of oncogenic signaling in lung cancer. Phosphorylation of GUK1 augments nucleotide pools and is important for G protein signaling and tumor proliferation.Schneider et al. identify guanylate kinase 1 (GUK1), a GDP-synthesizing enzyme, as a target of oncogenic signaling in lung cancer. Phosphorylation of GUK1 augments nucleotide pools and is important for G protein signaling and tumor proliferation.Jaime L. Schneider, Kiran Kurmi, Yutong Dai, Ishita Dhiman, Shakchhi Joshi, Brandon M. Gassaway, Christian W. Johnson, Nicole Jones, Zongyu Li, Christian P. Joschko, Toshio Fujino, Joao A. Paulo, Satoshi Yoda, Gerard Baquer, Daniela Ruiz, Sylwia A. Stopka, Liam Kelley, Andrew Do, Mari Mino-Kenudson, Lecia V. Sequist, Jessica J. Lin, Nathalie Y.R. Agar, Steven P. Gygi, Kevin M. Haigis, Aaron N. Hata, Marcia C. Haigishttps://www.cell.com/cell/fulltext/S0092-8674(25)00093-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 7, 2025

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