GPCR-mediated β-arrestin activation deconvoluted with single-molecule precisionReceptor-mediated β-arrestin activation requires relief of autoinhibition mediated by the respective C-terminal tails of the β2-adrenergic receptor and β-arrestin1. These processes depend not only on the degree of receptor tail phosphorylation but also on concurrent agonist-mediated receptor activation.Receptor-mediated β-arrestin activation requires relief of autoinhibition mediated by the respective C-terminal tails of the β2-adrenergic receptor and β-arrestin1. These processes depend not only on the degree of receptor tail phosphorylation but also on concurrent agonist-mediated receptor activation.Wesley B. Asher, Daniel S. Terry, G. Glenn A. Gregorio, Alem W. Kahsai, Alessandro Borgia, Bing Xie, Arnab Modak, Ying Zhu, Wonjo Jang, Alekhya Govindaraju, Li-Yin Huang, Asuka Inoue, Nevin A. Lambert, Vsevolod V. Gurevich, Lei Shi, Robert J. Lefkowitz, Scott C. Blanchard, Jonathan A. Javitchhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2822%2900392-0%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 28, 2022

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