Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodiesB cells are known to undergo sequential rounds of mutation and affinity-based selection, in sites known as germinal centers, to produce higher-affinity antibodies over time. This study finds that germinal centers formed in response to complex immune challenges support the differentiation of clonally diverse plasma cells, including some of low-antibody affinity, suggesting that high affinity is not the only factor driving the maturation of the antibody repertoire.B cells are known to undergo sequential rounds of mutation and affinity-based selection, in sites known as germinal centers, to produce higher-affinity antibodies over time. This study finds that germinal centers formed in response to complex immune challenges support the differentiation of clonally diverse plasma cells, including some of low-antibody affinity, suggesting that high affinity is not the only factor driving the maturation of the antibody repertoire.Adrien Sprumont, Ana Rodrigues, Simon J. McGowan, Colin Bannard, Oliver Bannardhttps://www.cell.com/cell/fulltext/S0092-8674(23)01173-X?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignNovember 11, 2023

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