Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individualsFine needle aspiration of lymph nodes in humans, reveals that SARS-CoV-2 vaccination induces neutralizing antibody-producing germinal centers, enhanced by repeated vaccination. Conversely, in patients receiving immunosuppressant medication, this process is disrupted resulting in stunted protective immune responses highlighting issues about vaccine and booster efficacy in patients with compromised immune systems.Fine needle aspiration of lymph nodes in humans, reveals that SARS-CoV-2 vaccination induces neutralizing antibody-producing germinal centers, enhanced by repeated vaccination. Conversely, in patients receiving immunosuppressant medication, this process is disrupted resulting in stunted protective immune responses highlighting issues about vaccine and booster efficacy in patients with compromised immune systems.Katlyn Lederer, Emily Bettini, Kalpana Parvathaneni, Mark M. Painter, Divyansh Agarwal, Kendall A. Lundgreen, Madison Weirick, Kavitha Muralidharan, Diana Castano, Rishi R. Goel, Xiaoming Xu, Elizabeth M. Drapeau, Sigrid Gouma, Jordan T. Ort, Moses Awofolaju, Allison R. Greenplate, Carole Le Coz, Neil Romberg, Jennifer Trofe-Clark, Gregory Malat, Lisa Jones, Mark Rosen, Daniela Weiskopf, Alessandro Sette, Behdad Besharatian, Mary Kaminiski, Scott E. Hensley, Paul Bates, E. John Wherry, Ali Naji, Vijay Bhoj, Michela Loccihttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2822%2900138-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 2, 2022

Powered by WPeMatico