Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumorsThis study demonstrates that extrachromosomal DNA (ecDNA) replication induces DNA double-strand breaks and activates the DNA damage response (DDR). The DDR pathways, such as alt-NHEJ, are critical for ecDNA maintenance in tumor cells. Mechanistic insights into ecDNA replication and maintenance unveil a therapeutic approach for treating tumors harboring ecDNA.This study demonstrates that extrachromosomal DNA (ecDNA) replication induces DNA double-strand breaks and activates the DNA damage response (DDR). The DDR pathways, such as alt-NHEJ, are critical for ecDNA maintenance in tumor cells. Mechanistic insights into ecDNA replication and maintenance unveil a therapeutic approach for treating tumors harboring ecDNA.Xing Kang, Xinran Li, Jiaqi Zhou, Yang Zhang, Lingyu Qiu, Congcong Tian, Zhiwen Deng, Xiaoyan Liang, Ziwei Zhang, Songlin Du, Suili Hu, Nan Wang, Zhen Yue, Yajing Xu, Yuan Gao, Junbiao Dai, Zhiquan Wang, Chuanhe Yu, Jinyi Chen, Yuchun Wu, Liangming Chen, Yuan Yao, Sitong Yao, Xinran Yang, Lixia Yan, Qing Wen, Olivia M. Depies, Kuiming Chan, Xiaohuan Liang, Gang Li, Zhike Zi, Xiangyu Liu, Haiyun Ganhttps://www.cell.com/cell/fulltext/S0092-8674(25)00414-3?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 29, 2025

Powered by WPeMatico