Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery
Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene deliveryBy swapping viral fusogenic proteins (which help viruses fuse with and enter host cells) with mammalian skeletal muscle fusogenic proteins, it is possible to create viral vectors specifically targeted to skeletal muscle for gene therapy of Duchenne muscular dystrophy in mouse models.By swapping viral fusogenic proteins (which help viruses fuse with and enter host cells) with mammalian skeletal muscle fusogenic proteins, it is possible to create viral vectors specifically targeted to skeletal muscle for gene therapy of Duchenne muscular dystrophy in mouse models.Sajedah M. Hindi, Michael J. Petrany, Elena Greenfeld, Leah C. Focke, Alyssa A.W. Cramer, Michael A. Whitt, Ramzi J. Khairallah, Christopher W. Ward, Jeffrey S. Chamberlain, Benjamin Podbilewicz, Vikram Prasad, Douglas P. Millayhttps://www.cell.com/cell/fulltext/S0092-8674(23)00330-6?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 19, 2023
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