Engineered commensals for targeted nose-to-brain drug deliveryShen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.Haosheng Shen, Nikhil Aggarwal, Beiming Cui, Guo Wei Foo, Yuanzhi He, Santosh Kumar Srivastava, Shengjie Li, Marcus Ze Xian Seah, Kwok Soon Wun, Hua Ling, In Young Hwang, Chun Loong Ho, Yung Seng Lee, Matthew Wook Changhttps://www.cell.com/cell/fulltext/S0092-8674(25)00046-7?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 6, 2025

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