CXCL12 drives natural variation in coronary artery anatomy across diverse populationsCoronary dominance is a clinically important developmental phenotype that dictates whether the left or right coronary arteries perfuse the back of the heart. Genome-wide association studies and downstream experiments identified CXCL12, a gene previously linked to coronary artery disease, as a driver of coronary dominance during fetal development. These findings show that common genetic variants influence developmental processes in humans, with implications for disease onset and revascularization efforts later in life.Coronary dominance is a clinically important developmental phenotype that dictates whether the left or right coronary arteries perfuse the back of the heart. Genome-wide association studies and downstream experiments identified CXCL12, a gene previously linked to coronary artery disease, as a driver of coronary dominance during fetal development. These findings show that common genetic variants influence developmental processes in humans, with implications for disease onset and revascularization efforts later in life.Pamela E. Rios Coronado, Jiayan Zhou, Xiaochen Fan, Daniela Zanetti, Jeffrey A. Naftaly, Pratima Prabala, Azalia M. Martínez Jaimes, Elie N. Farah, Soumya Kundu, Salil S. Deshpande, Ivy Evergreen, Pik Fang Kho, Qixuan Ma, Austin T. Hilliard, Sarah Abramowitz, Saiju Pyarajan, Daniel Dochtermann, Million Veteran Program, Scott M. Damrauer, Kyong-Mi Chang, Michael G. Levin, Virginia D. Winn, Anca M. Paşca, Mary E. Plomondon, Stephen W. Waldo, Philip S. Tsao, Anshul Kundaje, Neil C. Chi, Shoa L. Clarke, Kristy Red-Horse, Themistocles L. Assimeshttps://www.cell.com/cell/fulltext/S0092-8674(25)00161-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 6, 2025

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