Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-βAnalysis of intermediate conformations of the interaction between αvβ8 integrin and latent TGF-β suggests an activation mechanism that does not require release and diffusion of mature TGF-β, which has implications for current approaches to targeting TGF-β signaling therapeutically.Analysis of intermediate conformations of the interaction between αvβ8 integrin and latent TGF-β suggests an activation mechanism that does not require release and diffusion of mature TGF-β, which has implications for current approaches to targeting TGF-β signaling therapeutically.Melody G. Campbell, Anthony Cormier, Saburo Ito, Robert I. Seed, Andrew J. Bondesson, Jianlong Lou, James D. Marks, Jody L. Baron, Yifan Cheng, Stephen L. Nishimurahttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2819%2931392-3%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 17, 2020

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