Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signaturesA 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins contributing to vascular and systemic aging.A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins contributing to vascular and systemic aging.Yingjie Ding, Yuesheng Zuo, Bin Zhang, Yanling Fan, Gang Xu, Zhongyi Cheng, Shuai Ma, Shuaiqi Fang, Ao Tian, Dandan Gao, Xi Xu, Qiaoran Wang, Yaobin Jing, Mengmeng Jiang, Muzhao Xiong, Jiaming Li, Zichu Han, Shuhui Sun, Si Wang, Fuchu He, Jiayin Yang, Jing Qu, Weiqi Zhang, Guang-Hui Liuhttps://www.cell.com/cell/fulltext/S0092-8674(25)00749-4?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 26, 2025

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