Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism

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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolismOgawa et al. report that the intrinsically toxic RNA catabolites m6A, m6,6A, and i6A are detoxified through sequential action of ADK and ADAL, forming IMP. Disruption of this modified adenosine clearance pathway leads to toxic metabolite buildup, AMPK inhibition, and metabolic dysfunction in animal […]

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A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

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A conserved mechanism for the retrieval of polyubiquitinated proteins from ciliaCFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase to enable the selective and directional retrieval of polyubiquitinated proteins from cilia, a process essential for maintaining ciliary proteostasis.CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase to enable the selective and […]

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Private 5G installations and impacts – 20+ of the best

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Private 5G installations and impacts – 20+ of the bestPrivate 5G is gaining traction globally, with deployments from Tesla to Sinopec showing measurable productivity, safety, and efficiency gains, reinforcing forecasts of rapid market growth and momentum toward mainstream industrial adoption. Here are 23 of the best.  As is its way, analyst house SNS Telecom & […]

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Honeywell buys SparkMeter utility platforms – as industrial giants shrink to grow

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Honeywell buys SparkMeter utility platforms – as industrial giants shrink to growHoneywell has acquired SparkMeter’s utility platforms in a tuck-in deal to expand its smart energy software, aligning with its strategy of spinning off legacy units while bolstering digital energy-transition capabilities. In sum – what to know: Tuck-in acquisition – the purchase of SparkMeter’s platforms […]

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Test and Measurement: Testing an orbital data center at the ISS

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Test and Measurement: Testing an orbital data center at the ISSRed Hat, Axiom Space collaborated on a compact edge compute solution, or “orbital data center” for space A compact prototype for an orbital data center (image above) will soon be on its way to the International Space Station to boost space-based edge computing. The project, […]

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DNB gets capital injection by Malaysian carriers

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DNB gets capital injection by Malaysian carriersWith this new capital injection, each telco’s total contribution to DNB has risen to approximately MYR350 million In sum – what to know: $82.8M added to DNB – CelcomDigi, Maxis, and YTL Power increased their stakes to stabilize operations, pushing total investment to over MYR1 billion. Second 5G network […]

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