Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sitesAutophagy stimuli trigger Ca2+ transients/oscillations on the outer surface of the ER membrane, which induce phase separation of FIP200 for specification of autophagosome initiation sites on the ER. The metazoan-specific ER transmembrane autophagy protein EPG-4/EI24 controls the amplitude, frequency, and duration of the Ca2+ transient for autophagosome progression.Autophagy stimuli trigger Ca2+ transients/oscillations on the outer surface of the ER membrane, which induce phase separation of FIP200 for specification of autophagosome initiation sites on the ER. The metazoan-specific ER transmembrane autophagy protein EPG-4/EI24 controls the amplitude, frequency, and duration of the Ca2+ transient for autophagosome progression.Qiaoxia Zheng, Yong Chen, Di Chen, Hongyu Zhao, Yun Feng, Quan Meng, Yan Zhao, Hong Zhanghttps://www.cell.com/cell/fulltext/S0092-8674(22)01123-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignOctober 5, 2022

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