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A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cellsA small-molecule-only strategy enables reprogramming ESCs into embryo founder cells that give rise to a high-fidelity embryo model directly and efficiently. This embryo model replicates embryogenesis from initial cell fate specification through E8.5–E8.75-like organogenesis, capturing all key developmental features within a […]

Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipelineDing et al. report an AI-assisted workflow that enables top-down, cultivation-independent identification of human microbial bile acid metabolic enzymes.Ding et al. report an AI-assisted workflow that enables top-down, cultivation-independent identification of human microbial bile acid metabolic enzymes.Yong Ding, Xi Luo, Jiasheng Guo, Baiying Xing, […]

Vagal blockade of the brain-liver axis deters cancer-associated cachexiaVagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia. Blocking the right cervical vagus nerve with various invasive or non-invasive approaches alleviates cachexia, decoupling cachexia progression from tumor load, and synergizes with chemotherapy to improve overall health and survival in mice.Vagal dysfunction mediates […]

The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobilityAncient DNA from the Southern Caucasus reveals remarkable genetic continuity, with some mixing from Anatolia/Iran and the Eurasian Steppe, and shows that even periods of urbanization and increased mobility—including the spread of […]

FCC aims to boost subsea cable developmentA unanimous FCC agrees to update subsea cable regulations The Federal Communications Commission is updating its rules on subsea communications cables, aiming to streamline regulations and add more protections to the increasingly important underwater infrastructure that connects the world. All three current commissioners voted in favor of new proposed […]

Brookfield launches strategy to build AI infra at scaleBrookfield has already invested tens of billions in this sector and sees a “significant pipeline of opportunities” ahead In sum – what to know: Brookfield sets AI infra focus – The firm is launching a dedicated strategy to serve rising demand from hyperscalers, enterprises, and governments for […]

China Mobile’s revenues slightly down y-o-y in H1China Mobile ended H1 with a total of 599 million 5G subscribers In sum – what to know: Revenue dipped, profit lifted – China Mobile posted a 0.53% year-on-year revenue decline to CNY543.8B, but net profit rose 5% to CNY84.2B amid solid subscriber growth. 5G base hits 599M […]