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Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineageA Yersinia pestis genome from a Bronze Age domesticated sheep provides insight into the host range, evolution, and possible transmission scenarios of an ancient lineage of the plague-causing bacteria, previously identified exclusively in ancient humans.A Yersinia pestis genome […]

Engineering crop flower morphology facilitates robotization of cross-pollination and speed breedingA genome editing and AI-driven robotic system that overcomes floral barriers to facilitate automated hybrid breeding in tomato and soybean.A genome editing and AI-driven robotic system that overcomes floral barriers to facilitate automated hybrid breeding in tomato and soybean.Yue Xie, Tinghao Zhang, Minghao Yang, Hongchang […]

NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plantsNRT1.1B, a traditionally recognized nitrate receptor, can directly perceive the extracellular ABA signal to form a complex with the repressor protein SPX4, thereby releasing the SPX4-sequestered transcription factor NLP4 and initiating the ABA transcriptional response, while the competitive binding of nitrate and […]

VIVIT: Resolving trans-scale volumetric biological architectures via ionic glassy tissueLeveraging the chemical properties of ionic liquids, VIVIT transforms biological tissue into a glassy state, addressing long-standing challenges in the optical clearing field. This enables precise and reliable mapping of trans-scale biostructures, facilitating the discovery of a link between the synaptic inputs and brain-wide outputs of […]

Principles of cotranslational mitochondrial protein importSelective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal presequence but is delayed until a large domain emerges and prioritizes large multi-domain proteins. This multi-layered sorting mechanism enables cells to balance the import demands […]