Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptorCoronaviruses of the merbecovirus family have been thought to enter cells by using the host cell receptor DPP4. This study identifies a merbecovirus from Pipistrellus bats that is capable of entering cells from other mammals via ACE2, and it describes the structural basis for HKU5 interaction with human ACE2.Coronaviruses of the merbecovirus family have been thought to enter cells by using the host cell receptor DPP4. This study identifies a merbecovirus from Pipistrellus bats that is capable of entering cells from other mammals via ACE2, and it describes the structural basis for HKU5 interaction with human ACE2.Jing Chen, Wei Zhang, Yang Li, Chen Liu, Tianyi Dong, Huiyu Chen, Chunguang Wu, Jia Su, Bei Li, Wei Zhang, Ben Hu, Jingkun Jia, Cheng-Bao Ma, Yan Zhu, Xiangyang He, Ang Li, Kaiyi Pan, Haofeng Lin, Zishuo Guo, Cong Li, Libiao Zhang, Huan Yan, Peng Zhou, Wei Peng, Zheng-Li Shihttps://www.cell.com/cell/fulltext/S0092-8674(25)00144-8?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignFebruary 19, 2025

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