An evolved AAV variant enables efficient genetic engineering of murine T cellsBy combining structure-guided evolution and genome-wide screening, this work identifies an adeno-associated virus and co-factor that enable gene targeting at high efficiencies in mouse T lymphocytes, thus opening the path for T cell manipulations in murine models.By combining structure-guided evolution and genome-wide screening, this work identifies an adeno-associated virus and co-factor that enable gene targeting at high efficiencies in mouse T lymphocytes, thus opening the path for T cell manipulations in murine models.William A. Nyberg, Jonathan Ark, Angela To, Sylvanie Clouden, Gabriella Reeder, Joseph J. Muldoon, Jing-Yi Chung, William H. Xie, Vincent Allain, Zachary Steinhart, Christopher Chang, Alexis Talbot, Sandy Kim, Alan Rosales, L. Patrick Havlik, Harold Pimentel, Aravind Asokan, Justin Eyquemhttps://www.cell.com/cell/fulltext/S0092-8674(22)01535-5?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJanuary 13, 2023

Powered by WPeMatico